Alex’s Lemonade Stand Foundation Crazy 8 Initiative Program: Childhood Cancer Predisposition

Alex’s Lemonade Stand Foundation Crazy 8 Initiative Program: Childhood Cancer Predisposition

The Alex’s Lemonade Stand Foundation (ALSF) is inviting applications for the Crazy 8 Initiative Program on Childhood Cancer Predisposition. ALSF emerged from the inspiring story of 4-year-old Alexandra “Alex” Scott, who fought cancer and raised money to find cures for all children with cancer through her lemonade stand. Today, ALSF is a leading funder of pediatric cancer research in the U.S. and Canada, supporting over 1,000 research projects and providing programs for families affected by childhood cancer.

The Crazy 8 Initiative Program focuses on understanding childhood cancer predisposition and prevention. It encourages collaboration between two or more institutions with different areas of research expertise, ideally including a patient advocate on the team. Proposals should address a topic related to pediatric/adolescent cancer predisposition and be responsive to at least one of the five areas of focus outlined by ALSF.

The award selection process involves three stages: a letter of intent, a full proposal, and a virtual presentation to ALSF leadership and the Crazy 8 Scientific Advisory Board. Proposals will be evaluated based on innovation, scientific soundness, significance, and potential impact on improving the lives of children with cancer.

The application timeline is as follows:

Letter of Intent Due: January 8th, 2024
Invitation to Submit Full Proposal: February 2024
Full Proposals Due: April 17th, 2024
Invitation to Present: July 2024
Finalist Presentations (Virtual): Week of August 19th
Grant Start Date: October 2024

To be eligible, principal investigators and co-investigators must have an MD, PhD, or MD/PhD (or equivalent) and be appointed as faculty at an academic institution. They must also have a track record of publication and funding productivity demonstrating their capability to accomplish the proposed project. Institutions may be based in the United States or abroad, and applicants need not be U.S. citizens.

For more information and detailed guidelines, please download the document here. 2024_crazy_8_final.pdf (


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